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KMID : 1001920210640030367
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Journal of Korean Neurosurgical Society
2021 Volume.64 No. 3 p.367 ~ p.373
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Cell Lineage, Self-Renewal, and Epithelial-to-Mesenchymal Transition during Secondary Neurulation
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Kawachi Teruaki
Tadokoro Ryosuke
Takahashi Yoshiko
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Abstract
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Secondary neurulation (SN) is a critical process to form the neural tube in the posterior region of the body including the tail. SN is distinct from the anteriorly occurring primary neurulation (PN); whereas the PN proceeds by folding an epithelial neural plate, SN precursors arise from a specified epiblast by epithelial-to-mesenchymal transition (EMT), and undergo self-renewal in the tail bud. They finally differentiate into the neural tube through mesenchymal-to-epithelial transition (MET). We here overview recent progresses in the studies of SN with a particular focus on the regulation of cell lineage, self-renewal, and EMT/MET. Cellular mechanisms underlying SN help to understand the functional diversity of the tail in vertebrates.
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KEYWORD
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Cell lineage, Cell self renewal, Epithelial-mesenchymal transition, Chickens
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